A palladium-catalyzed enantioselective carboannulation of 1,3-dienes and aryl iodides has been established by using a BINOL-based phosphoramidite ligand. This reaction proceeded via a tandem Heck-type insertion and asymmetric intramolecular Tsuji-Trost allylic alkylation, providing indane derivatives with high levels of enantioselectivity (up to >99% ee).
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| http://dx.doi.org/10.1039/c8cc04641g | DOI Listing |
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