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Adult Henolch-Schonlein purpura: multiorgan failure in the setting of a purpuric rash. | LitMetric

Adult Henolch-Schonlein purpura: multiorgan failure in the setting of a purpuric rash.

BMJ Case Rep

Internal Medicine, University of Tennessee at Chattanooga, College of Health Education and Professional Studies, Chattanooga, Tennessee, USA.

Published: August 2018

AI Article Synopsis

  • A 66-year-old man with a history of heart failure, atrial fibrillation on warfarin, and chronic kidney disease experienced sudden shortness of breath and developed purpuric lesions on his legs.
  • Lab tests showed acute anemia, high blood clotting levels, and worsening kidney function, while initial scopes suggested ischaemic colitis.
  • A skin biopsy revealed leucocytoclastic vasculitis linked to Henoch-Schonlein purpura, leading to successful treatment with oral steroids, stabilization of bleeding, and eventual discharge from dialysis.

Article Abstract

We report a 66-year-old man with a history of congestive heart failure, atrial fibrillation on warfarin therapy and chronic kidney disease that presented with acute dyspnoea. He had multiple palpable purpuric lesions on his bilateral lower extremities. Laboratory findings supported acute anaemia with no obvious bleeding source, supratherapeutic international normalised ratio and acute on chronic kidney injury. Oesophogastroduodenoscopy and colonoscopy initially suggested ischaemic colitis. The patient's legs were treated symptomatically with topical steroids. He later developed acute large volume bloody diarrhoea that made him haemodynamically unstable. Punch biopsy of the skin was consistent with leucocytoclastic vasculitis and direct immunofluorescence demonstrated immunoglobulin A and C3 deposits consistent with Henoch-Schonlein purpura. The patient was treated with oral steroids. Bleeding stabilised and rash resolved. Steroids were successfully tapered. The patient was discharged on haemodialysis but ultimately this was able to be discontinued.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088291PMC
http://dx.doi.org/10.1136/bcr-2018-224816DOI Listing

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