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Treating Chronic Pruritus: Are We at the Threshold of a Breakthrough?
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July 2024
Department of Dermatology, University of California at San Francisco, San Francisco, California, USA.
Chronic pruritis, characterized by persistent itchiness lasting more than six weeks, affects up to 15% of the population, significantly impairing quality of life. Despite its prevalence and impact, there is an absence of FDA-approved medications specifically for the treatment of chronic pruritus, highlighting a significant unmet need in dermatology. Advancements in dermatologic medications, however, including the development of biologics and Janus kinase (JAK) inhibitors, signal potential breakthroughs in pruritus management through a radically different mechanism of action that focuses on their effect on the nervous system.
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Ann Dermatol Venereol
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Faculté de médecine, université de Strasbourg, hôpitaux universitaires de Strasbourg (HUS), clinique dermatologique, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:
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