Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a sp. has been isolated as an endophyte from the medicinal plant . Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.
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| http://dx.doi.org/10.1080/14786419.2018.1489393 | DOI Listing |
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