Treatment of the autoimmune and immune-dysregulatory features of patients with STAT1 GOF or STAT3 GOF disease remains challenging. Jakinibs have been used to treat the severe immune-dysregulation in patients with either GOF or GOF mutations.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322659PMC
http://dx.doi.org/10.1016/j.jaci.2018.07.020DOI Listing

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