AI Article Synopsis
- Chronic itch is a significant symptom associated with cutaneous T cell lymphoma (CTCL).
- In a 2018 study published in Neuron, researchers led by Han discovered that an extracellular miRNA contributes to this itch sensation.
- This miRNA activates a specific receptor, TRPA1, on sensory neurons, playing a key role in the itch response.
Article Abstract
Chronic itch is a major symptom of cutaneous T cell lymphoma (CTCL). In this issue of Neuron, Han and colleagues (2018) provide evidence that one of the itch mediators in CTCL is an extracellular miRNA that directly activates TRPA1 on sensory neurons.
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| http://dx.doi.org/10.1016/j.neuron.2018.07.040 | DOI Listing |
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