Introduction: Implanted intrathecal drug delivery systems (IDDS) are increasingly used in the treatment of spasticity and in patients with refractory pain. Literature discussing complications associated with intrathecal pump placement is widely available. However, reports of complications following the removal of chronically placed catheters are scarce. We reviewed our series of patients who had surgery to remove the intrathecal catheter.
Methods: Retrospective review was performed for all patients who underwent surgery to remove a catheter linked to an IDDS between 2010 and 2016. Patients older than 18 years were included in final analysis. Demographic (including age at removal, sex, BMI, and comorbidities) and etiologic characteristics (indications of IDDS implant and explant, interval between implant and explant, and concomitant surgery) were analyzed. Simple logistic regression was performed to seek any potential predictor of complications.
Results: Fifty-nine patients underwent removal of their intrathecal catheter after variable periods (mean interval of 189 months). On eight occasions, patients developed complications after catheter removal (mean interval between implant and explant was 76 months for these cases). Retained catheter was the cause of complications in half of these occasions. Persistent cerebrospinal fluid leak was the next most common complication, with requirement of an external ventricular drain and lumbar drain to facilitate wound healing on two separate occasions.
Conclusion: Removal of an intrathecal catheter from IDDS systems may cause complications that in some cases require additional surgery.
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http://dx.doi.org/10.1111/ner.12799 | DOI Listing |
Surg Neurol Int
November 2024
Department of Neurosurgery, College of Medicine and Life Sciences, University of Toledo, Toledo, United States.
Background: (AX) is an aerobic Gram-negative opportunistic bacteria known to inhabit various environments and is most commonly associated with nosocomial infections in immune-compromised patients. Although rare, AX can cause a variety of neurological infections, such as meningitis, ventriculitis, and osteomyelitis. Intravascular catheters, intrathecal pumps, and contaminated surgical instruments are potential vectors for such patients.
View Article and Find Full Text PDFNeuropsychopharmacol Rep
March 2025
Department of Anesthesiology and Critical Care Medicine, Saitama Medical Center, Jichi Medical University, Saitama-Shi, Saitama, Japan.
Background: Cerebrospinal fluid (CSF) levels of orexin show a cyclic diurnal variation in healthy subjects, which is diminished in patients with certain diseases. However, possible circadian variations in orexin levels in critically ill patients remain unknown. In this study, we evaluated the orexin concentrations in the CSF and their diurnal variation in patients undergoing thoracic aortic aneurysm repair with lumbar intrathecal catheterization for CSF drainage after non-neurosurgery.
View Article and Find Full Text PDFRev Med Inst Mex Seguro Soc
May 2024
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 3, Servicio de Anestesiología. San Juan del Río, Querétaro, México.
Background: Spinal anesthesia can present various complications, one of which is the breakage of a spinal needle within the intrathecal space, which is one of the least frequent complications and it may be serious. A case of spinal needle breakage is presented, pointing out its risk factors and recommendations to reduce it.
Clinical Case: 5-year-old female patient, who was scheduled for removal of translocated intrauterine device causing chronic pain.
Neurobiol Dis
November 2024
Department of Medical Biosciences, Clinical Chemistry, Umeå University, SE-901 85 Umeå, Sweden. Electronic address:
Mutations in superoxide dismutase-1 (SOD1) are a cause of hereditary amyotrophic lateral sclerosis (ALS) through a gain-of-function mechanism involving unfolded mutant SOD1. Intrathecal gene therapy using the antisense-oligo-nucleotide drug tofersen to reduce SOD1 expression delays disease progression and has recently been approved in the United States and the European Union. However, the discovery of children homozygous for inactivating SOD1 mutations developing the SOD1 Deficiency Syndrome (ISODDES) with injury to the motor system suggests that a too low SOD1 antioxidant activity may be deleterious in humans.
View Article and Find Full Text PDFAnn Plast Surg
November 2024
From the Department of Plastic & Reconstructive Surgery, Monash Health, Melbourne, Victoria, Australia.
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