In mid-March 2015, a mother and her teenage daughter and son from Syria presented to a Syrian American Medical Society (SAMS) refugee clinic in the Beqaa Valley in Lebanon with the chief complaints of hair loss together with weakness and numbness of their lower extremities. They reported that on March 1, a military foe of their relative had given him several boxes of Middle Eastern cookies which were consumed by over 20 members of their families and neighbors. Soon after the consumption, most members of the households developed symptoms including abdominal pain, nausea, vomiting, and constipation. Later, many of the affected individuals, including the three who presented to the clinic, had pain and weakness in the extremities, skin lesions, and hair loss. Two subjects died inside Syria of kidney failure. In this report, we describe the diagnostic challenges faced until the arrival to the diagnosis of thallium intoxication and the therapeutic obstacles to getting adequate therapy. We also report the results of a survey sent to all subjects in the affected households and discuss the context of lawlessness that led to this intoxication and perhaps other cases.
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http://dx.doi.org/10.4103/ajm.AJM_17_18 | DOI Listing |
J Environ Sci Health A Tox Hazard Subst Environ Eng
October 2024
Arch Toxicol
December 2024
Department of Nephrology and Hypertension, Dokkyo Medical University, Tochigi, Japan.
Toxicol Lett
July 2024
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. Electronic address:
Sodium para-aminosalicylic acid (PAS-Na) treatment for manganese (Mn) intoxication has shown efficacy in experimental and clinical studies, giving rise to additional studies on its efficacy for lead (Pb) neurotoxicity and its associated mechanisms of neuroprotection. The difference between PAS-Na and other metal complexing agents, such as edetate calcium sodium (CaNa-EDTA), is firstly that PAS-Na can readily pass through the blood-brain barrier (BBB), and complex and facilitate the excretion of manganese and lead. Secondly, PAS-Na has anti-inflammatory effects.
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