Cases of thallium intoxication in Syria: A diagnostic and a therapeutic challenge.

Avicenna J Med

Data and Research Committee, Syrian American Medical Society, Washington, DC 20005, USA.

Published: January 2018

In mid-March 2015, a mother and her teenage daughter and son from Syria presented to a Syrian American Medical Society (SAMS) refugee clinic in the Beqaa Valley in Lebanon with the chief complaints of hair loss together with weakness and numbness of their lower extremities. They reported that on March 1, a military foe of their relative had given him several boxes of Middle Eastern cookies which were consumed by over 20 members of their families and neighbors. Soon after the consumption, most members of the households developed symptoms including abdominal pain, nausea, vomiting, and constipation. Later, many of the affected individuals, including the three who presented to the clinic, had pain and weakness in the extremities, skin lesions, and hair loss. Two subjects died inside Syria of kidney failure. In this report, we describe the diagnostic challenges faced until the arrival to the diagnosis of thallium intoxication and the therapeutic obstacles to getting adequate therapy. We also report the results of a survey sent to all subjects in the affected households and discuss the context of lawlessness that led to this intoxication and perhaps other cases.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057163PMC
http://dx.doi.org/10.4103/ajm.AJM_17_18DOI Listing

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Article Synopsis
  • Thallium (Tl) is a highly toxic heavy metal linked to accidental poisoning and can cause severe health issues including kidney failure.
  • In a study on rats, intraperitoneal administration of Tl led to significant kidney dysfunction, characterized by high calcium deposits and mitochondrial issues in a specific kidney region called the medullary thick ascending limb (mTAL).
  • The research found that inhibiting a specific kidney transporter helped reduce Tl accumulation and its damaging effects, which could lead to new treatment strategies for Tl poisoning and improve diagnostic methods for related kidney damage.
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Treatment of manganese and lead poisoning with sodium para-aminosalicylic acid: A contemporary update.

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Sodium para-aminosalicylic acid (PAS-Na) treatment for manganese (Mn) intoxication has shown efficacy in experimental and clinical studies, giving rise to additional studies on its efficacy for lead (Pb) neurotoxicity and its associated mechanisms of neuroprotection. The difference between PAS-Na and other metal complexing agents, such as edetate calcium sodium (CaNa-EDTA), is firstly that PAS-Na can readily pass through the blood-brain barrier (BBB), and complex and facilitate the excretion of manganese and lead. Secondly, PAS-Na has anti-inflammatory effects.

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