AI Article Synopsis
- The research evaluates the health hazards of the lead halide perovskite CHNHPbI, which is used in solar cells, by testing its effects on various human and murine cell types.
- In experiments, CHNHPbI caused significant cell death in hippocampal neurons and neuroblastoma cells, while lung epithelial cells experienced altered growth and structure without dying.
- The study emphasizes the need for further investigation into the potential health and environmental risks associated with both short-term and long-term exposure to CHNHPbI.
Article Abstract
New technologies launch novel materials; besides their performances in products, their health hazards must be tested. This applies to the lead halide perovskite CHNHPbI as well, which offers fulgurate applications in photovoltaic devices. We report the effects of CHNHPbI photovoltaic perovskites in human lung adenocarcinoma epithelial cells (A549), human dopaminergic neuroblastoma cells (SH-SY5Y) and murine primary hippocampal neurons by using multiple assays and electron microscopy studies. In cell culture media the major part of the dissolved CHNHPbI has a strong cell-type dependent effect. Hippocampal primary neurons and neuroblastoma cells suffer a massive apoptotic cell death, whereas exposure to lung epithelial cells dramatically alters the kinetics of proliferation, metabolic activity and cellular morphology without inducing noticeable cell death. Our findings underscore the critical importance of conducting further studies to investigate the effect of short and long-term exposure to CHNHPbI on health and environment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062200 | PMC |
| http://dx.doi.org/10.1039/c5tx00303b | DOI Listing |
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