Biological Activity of Steroids from the Marine Gastropods Collected from South West Coast of India.

Avicenna J Med Biotechnol

Department of Chemical Oceanography, Faculty of Marine Sciences, Cochin University of Science and Technology, Cochin-682016, India.

Published: January 2018

Background: The purpose of this study was to investigate the sterol profiling and predict the pharmacological potential of marine gastropod , collected from mangrove ecosystem in the South west coast of India.

Methods: Sterol fractions were separated from the crude lipids using 15% ethyl acetate. Ethyl acetate fractions were dried under ultrahigh purity N and analyzed using GC-MS. The biological activity was predicted using the software CLC-Pred; predictions of cytotoxicity for tumor and non-tumor cell lines and PASS.

Results: This study proved the existence of four sterols, of which cholesterol was abundant. It was found that most of the steroids profiled from displayed activity against reproductive system as well as skin related diseases.

Conclusion: The predicted anti infertility and skin related activity of the steroids identified from the marine gastropod is useful to attract industrial interest towards this species which will be helpful in rising new combinations with added therapeutic and nutritional worth.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064002PMC

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