Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition.

Cell Metab

Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Published: August 2018

Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463890PMC
http://dx.doi.org/10.1016/j.cmet.2018.07.009DOI Listing

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