AI Article Synopsis
- Human longevity is influenced by multiple factors, including genetics and environment, with a focus on specific genetic polymorphisms like FOXO3, SOD2, APOE, and SIRT1.
- The study found a connection between the FOXO3 GG genotype and gender, while lifestyle and biochemical traits impacted longevity; however, factors like DNA damage and oxidative stress did not show a correlation with lifespan.
- The research suggests FOXO3 as a potential candidate gene for longevity, highlighting its implications for healthcare related to aging and encouraging further studies on gene regulation in elderly populations.
Article Abstract
Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082243 | PMC |
| http://dx.doi.org/10.1590/1678-4685-GMB-2017-0169 | DOI Listing |
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