AI Article Synopsis
- The study investigated the effects of cannabidiol (CBD) on oral wound healing in rats by inducing standardized ulcers on their tongues and administering CBD at varying doses.
- Although CBD treatment didn't affect the size of the wounds after 3 and 7 days, it did show a reduction in inflammation in the first 3 days compared to the control group.
- Ultimately, while CBD demonstrated anti-inflammatory properties early in the wound healing process, it did not lead to significant clinical improvement in the healing of oral ulcers.
Article Abstract
The effects of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, were assessed on oral wound healing in an in vivo model. Standardized ulcers were induced in 60 Wistar rats using a 5-mm biopsy punch on the midline of the ventral tongue. Animals received intraperitoneal injections of CBD at doses of 0 (control), 5, and 10 mg/kg daily. Animals were weighed daily, and wound healing was clinically and histologically evaluated after 3 and 7 days of treatment. CBD treatment did not influence the wound area of ulcerative lesions at either observation time. Conversely, microscopic findings revealed that at Day 3 postwounding, CBD-treated lesions exhibited significantly lower inflammatory scores than those in the control group. However, this difference was not observed at Day 7. Collectively, these findings indicate that CBD exert an antiinflammatory effect in early phase of wound healing process although it was not sufficient promote clinical improvement of oral traumatic ulcerative lesions.
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| http://dx.doi.org/10.1002/ptr.6165 | DOI Listing |
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