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Resolving the bone - optimizing decalcification in spatial transcriptomics and molecular pathology.
J Histotechnol
December 2024
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bone tissue poses critical roadblocks for spatial transcriptomics and molecular pathology due to a combination of its dense, calcified matrix and inadequate preservation of biomolecules in conventional decalcification. Decalcification is a complex and nuanced histological process to concomitantly preserve nucleic acids, proteins, and tissue architecture, ensuring molecular integrity for downstream assays. However, commonly used agents like formic and hydrochloric acids, while efficient, can degrade biomolecules to varying extents, complicating assays such as PCR, sequencing, immunohistochemistry, and hybridization.
View Article and Find Full Text PDFDust event identification and characterization with one-year online observations in Beijing.
Sci Total Environ
December 2024
Aerosol and Haze Laboratory, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
Dust storms have a profound impact on air quality, atmospheric chemistry, and human well-being by carrying vast amounts of particles over distances of thousands of kilometers. However, the overall characteristics of these dust events and their influence on secondary pollution in the northern China region are not yet well understood, due to a lack of long-term, comprehensive observations and objective identification techniques. Based on principal component analysis combined with high-time-resolution observations of particulate matter components, here we developed a robust method to identify dust storm events and identified 14 dust events in Beijing in 2019.
View Article and Find Full Text PDFCoupling artificial neural network and sperm swarm optimization for soil temperature prediction at multiple depths.
Environ Sci Pollut Res Int
October 2024
Department of Water Engineering, University of Tabriz, Tabriz, Iran.
Soil temperature (ST) stands as a pivotal parameter in the realm of water resources and irrigation. It serves as a guide for farmers, enabling them to determine optimal planting and fertilization timings. In the backdrop of regions like Iran, where water resources are scarce, a proficient and economical prediction model for ST, particularly at lower depths, becomes imperative.
View Article and Find Full Text PDFScience development study for the Atacama Large Aperture Submillimeter Telescope (AtLAST): Solar and stellar observations.
Open Res Eur
July 2024
Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California, CA 91125, USA.
Observations at (sub-)millimeter wavelengths offer a complementary perspective on our Sun and other stars, offering significant insights into both the thermal and magnetic composition of their chromospheres. Despite the fundamental progress in (sub-)millimeter observations of the Sun, some important aspects require diagnostic capabilities that are not offered by existing observatories. In particular, simultaneously observations of the radiation continuum across an extended frequency range would facilitate the mapping of different layers and thus ultimately the 3D structure of the solar atmosphere.
View Article and Find Full Text PDFA synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis.
Front Bioeng Biotechnol
July 2024
Department of Bioengineering, Imperial College London, London, United Kingdom.
Osteoarthritis (OA) is a common chronic disease largely driven by mechanical factors, causing significant health and economic burdens worldwide. Early detection is challenging, making animal models a key tool for studying its onset and mechanically-relevant pathogenesis. This review evaluate current use of preclinical models and progressive measurement techniques for analysing biomechanical factors in the specific context of the clinical OA phenotypes.
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