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Analysis and Isolation of Potential Artemisinin Precursors from Waste Streams of Extraction. | LitMetric

Analysis and Isolation of Potential Artemisinin Precursors from Waste Streams of Extraction.

ACS Omega

Process Chemistry Team, Clinton Health Access Initiative, 800 N. Five Points Rd, West Chester, Pennsylvania 19380, United States.

Published: July 2018

AI Article Synopsis

Article Abstract

High-performance liquid chromatography, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry methods were developed to analyze the process waste streams of extraction. Results from these methods suggested that the final waste from the extraction process could serve as a source of dihydroartemisinic acid (DHAA) that could be converted to additional artemisinin. Two additional impurities were isolated and identified in the waste material as well as in leaf samples. That these impurities also appear as side-products in chemical transformations of DHAA to artemisinin supports the conclusion that the in vivo transformation proceeds as nonspecific oxidations. These impurities do not appear in isolated artemisinin. A simple, high-yielding procedure for recovery of DHAA from the primary waste stream was developed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068693PMC
http://dx.doi.org/10.1021/acsomega.8b00974DOI Listing

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