With the expansion of Intelligent Transport Systems (ITS) in smart cities, the shared bicycle has developed quickly as a new green public transportation mode, and is changing the travel habits of citizens heavily across the world, especially in China. The purpose of the current paper is to provide an inclusive review and survey on shared bicycle besides its benefits, history, brands and comparisons. In addition, it proposes the concept of the Internet of Shared Bicycle (IoSB) for the first time, as far as we know, to find a feasible solution for those technical problems of the shared bicycle. The possible architecture of IoSB in our opinion is presented, as well as most of key IoT technologies, and their capabilities to merge into and apply to the different parts of IoSB are introduced. Meanwhile, some challenges and barriers to IoSB's implementation are expressed thoroughly too. As far as the advice for overcoming those barriers be concerned, the IoSB's potential aspects and applications in smart city with respect to technology development in the future provide another valuable further discussion in this paper.
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http://dx.doi.org/10.3390/s18082581 | DOI Listing |
Accid Anal Prev
January 2025
Department of Civil Engineering, The University of British Columbia, Canada.
Proactive and holistic safety management approaches should consider multi-modal crash risk. Cyclist crash risk should be prioritized given the high-severity of vehicle-cyclist crashes. Cyclist crash risk is difficult to quantify given the sparse nature of cyclist collisions and collisions in general.
View Article and Find Full Text PDFNat Med
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically validated for ultrasensitive ctDNA detection at 1-3 ppm of ctDNA with 99.
View Article and Find Full Text PDFNat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFFront Public Health
January 2025
Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
Background: Shared micromobility programs (SMPs) are integral to urban transport in US cities, providing sustainable transit options. Increased use has raised safety concerns, notably about helmet usage among e-scooter and e-bicycle riders. Prior studies have shown that head and upper extremity injuries have risen with SMP adoption, yet data on helmet use remains sparse.
View Article and Find Full Text PDFChromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer (NSCLC) cohort identified that genetic alterations in six genes, including FAT1, result in homologous recombination (HR) repair deficiencies and CIN. Using orthogonal genetic and experimental approaches, we demonstrate that FAT1 alterations are positively selected before genome doubling and associated with HR deficiency.
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