Collagenous gastritis is an uncommon gastrointestinal disease in children. Its cause remains uncertain. It may present as severe hypoproteinaemia manifesting as generalized oedema. We report a 15 months old female who presented with pica, generalized body oedema and diarrhoea. Diagnostic workup revealed gastric replacement of the lamina propria by hyalinized collagen on histology. This case seeks to highlight the need for early paediatric gastroenterology referral including oesophagogastroduodenoscopy with multiple tissue biopsies as part of a broad diagnostic workup in children with non-specific gastrointestinal symptoms to improve diagnostic yield and enable accurate histologic diagnosis, so that appropriate therapy can be timeously applied.
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Article Synopsis
- Collagenous gastritis (CG) and Lymphocytic gastritis (LG) are uncommon forms of gastritis characterized by specific cellular changes, and this study aimed to analyze their prevalence and features in children over a 23-year period.
- In a review of 31 pediatric cases, CG was found in 11 patients (35.5%), while LG was identified in 20 patients (64.5%), most of whom presented with gastrointestinal symptoms and iron deficiency anemia.
- Treatment typically involved iron supplements, proton pump inhibitors, and dietary changes, with most patients showing improvement in hemoglobin levels, although some required ongoing treatment and a follow-up endoscopy showed no significant histopathological changes
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