This review summarises the current knowledge of risk factors, diagnostic work-up, and treatment of superficial vein thrombosis (SVT). SVT most often affects varicose superficial veins of the lower extremity. The diagnosis is based on clinical signs and may be supplemented by duplex ultrasound. The treatment of SVT aims at relieving symptoms and preventing progression into the deep vein system. Recent studies indicate benefit of anticoagulant therapy in selected cases of SVT.
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Eur Heart J
December 2024
Department of Cardiology, IRCCS Istituto Auxologico Italiano, Faint and Fall Research Centre, S. Luca Hospital, Piazzale Brescia 20, Milano 20149, Italy.
Background And Aims: Identifying the haemodynamic mechanism of autonomic syncope is the essential pre-requisite for effective and personalized therapy aimed at preventing recurrences. The present study assessed the diagnostic efficacy of a two-step assessment.
Methods: Multicentre prospective, cross-sectional, observational study.
Blood
December 2024
University of Pavia, Pavia, Italy.
The term "unexplained cytopenia" is used to describe a condition characterized by peripheral blood (PB) cytopenia that cannot be attributed to identifiable causes using conventional tests or to any concomitant diseases. Unexplained cytopenia requires clinical attention and further investigation to identify individuals at risk of developing a hematologic neoplasm. The available evidence suggests that somatic mutation analysis may effectively complement the diagnostic work-up and clinical management of unexplained cytopenia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Background: We hypothesise that improved diagnostic precision, operationalised by adding amyloid positron emission tomography (PET) to the diagnostic work-up in a memory clinic, is beneficial for long-term health and healthcare cost outcomes. We investigated whether a more precise diagnosis influenced institutionalisation and mortality incidence trajectories, and annual healthcare costs over a period up to eight years.
Method: Between October 2014 and December 2016, patients from the Amsterdam Dementia Cohort were offered an amyloid-PET as part of their diagnostic work-up.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Tau-PET is a diagnostic tool with high sensitivity and high specificity for discriminating Alzheimer Disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in "real-world" clinical practice, however, remains to be established. We hypothesize that tau-PET will lead to some changes of the pre-PET clinical diagnosis and will improve diagnostic certainty and patient management in patients with considerable diagnostic uncertainty.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Several new blood-based biomarkers (BBMs) of Alzheimer's disease and related neuropathologies have completed late-stage validation and are beginning to be used in the clinical setting. However, the role of BBMs in various clinical settings, especially their specific context-of-use, remains an open question for the field. Several studies are beginning to systematically collect information on BBM real-word diagnostic performance, but as BBMs transition from research settings to clinical implementation, experience from clinical providers in specialty centers can inform and guide use.
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