AI Article Synopsis
- A 2-year-old girl diagnosed with Graves' disease (GD) experienced early puberty and advanced bone age at the onset of her condition.
- Despite initial tall stature, her linear growth slowed after starting anti-thyroid treatment, yet breast development was noted at age 6.
- Hormonal tests indicated normal pubertal levels, leading to the initiation of gonadal suppression therapy, resulting in her adult height being slightly above expected genetic potential, marking this as the first documented case of early sexual development linked to GD in a female.
Article Abstract
We describe the case of a girl diagnosed with Graves' disease (GD) at 2 yr of age, who developed early puberty. Preoperative examination for craniosynostosis revealed thyrotoxicosis. While she was tall and her bone age was advanced at GD onset, her linear growth attenuated after commencement of anti-thyroid treatment. However, at approximately 6 yr of age, breast budding was recognized. Hormonal analysis revealed pubertal levels of LH response to a GnRH stimulation test and serum E2. Gonadal suppression therapy with GnRH agonist was initiated, and her adult stature slightly exceeded the genetic potential. Although accelerated growth and skeletal maturation are often reported to occur at GD onset in prepubertal patients, early puberty is unusual, and this is the first reported case of sexual precocity in a girl with GD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073066 | PMC |
| http://dx.doi.org/10.1297/cpe.27.165 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessing the Diagnostic Performance of Automated Pituitary Gland Volume Measurement for Idiopathic Central Precocious Puberty.
J Clin Med
December 2024
Departments of Radiology, Eulji University Hospital, Eulji University College of Medicine, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Republic of Korea.
It is known that the pituitary gland volume (PV) in idiopathic central precocious puberty (IPP) is significantly higher than in healthy children. However, most PV measurements rely on manual quantitative methods, which are time-consuming and labor-intensive. This study aimed to automatically measure the PV of patients with IPP using artificial intelligence to accurately quantify the correlation between IPP and PV, and to improve the efficiency of diagnosing IPP.
View Article and Find Full Text PDFChildhood obesity and central precocious puberty.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Second Ward of Endocrinology Department, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000.
Central precocious puberty (CPP) is an endocrine disorder in children caused by the early activation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to elevated gonadotropin-releasing hormone (GnRH), which triggers the development of gonads and the secretion of sex hormones. This eventually results in the development of internal and external genitalia and secondary sexual characteristics. CPP significantly affects the physical and mental health of children and may increase the risk of various adult diseases.
View Article and Find Full Text PDFBasal and stimulated inhibin B in pubertal disorders.
J Clin Endocrinol Metab
January 2025
3Department of Metabolism, Digestion and Reproduction, Imperial College London.
Pubertal disorders in the form of delayed puberty (DP) or precocious puberty (PP) can cause considerable anxiety to both children and parents. Since the clinical and biochemical signatures of self-limiting and permanent conditions overlap considerably, it can be hard to determine whether to offer them reassurance or intervention. Researchers have thus long been searching for a robust test to indicate that the process of endogenous puberty is underway and is likely to proceed to completion.
View Article and Find Full Text PDFPerfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study.
Front Endocrinol (Lausanne)
January 2025
Department of Pediatrics, Hainan Medical University School of Pediatrics, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
Background And Objective: The incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore the impact of perfluorinated endocrine disruptors on CPP through metabolomics analysis in girls from Hainan Province, China.
Methods: Serum samples from 100 girls with CPP and 100 healthy controls were collected.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!