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| http://dx.doi.org/10.1179/002436312804827082 | DOI Listing |
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Effect of prebiotic supplementation on health status in adults with prediabetes: a systematic review and meta-analysis of randomized clinical trials.
J Nutr
January 2025
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
Prediabetes with a considerable progression rate is a primary risk factor for type 2 diabetes, if left untreated. Dietary interventions examining the health effects of prebiotic consumption on health status have been studied in subjects with prediabetes but the results are controversial. This study aimed to investigate whether prebiotic consumption can favorably alter metabolic status as well as anthropometric features in subjects with prediabetes.
View Article and Find Full Text PDFBurden of vascular risk factors by age, sex, ethnicity and deprivation in young adults with and without newly diagnosed type 2 diabetes.
Diabetes Res Clin Pract
January 2025
Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester General Hospital, Leicester LE5 4PW UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and University of Leicester, Leicester LE5 4PW UK; Leicester Real World Evidence Unit, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW UK.
Aims: Do associations between age at diagnosis of type 2 diabetes and vascular risk factors vary by ethnicity and deprivation?
Methods: Utilising the Clinical Practice Research Datalink, we matched 16-50-year-old individuals with newly diagnosed type 2 diabetes to ∼10 individuals without using sex, age and primary care practice. Differences in BMI, obesity, LDL-cholesterol, HbA1c, and hypertension between individuals with vs without type 2 diabetes across sex, age, ethnicity and deprivation quintiles were explored using generalised linear models.
Results: We included 108,061 individuals (45.
Mandibular trabecular bone pattern before and two years after medical or surgical obesity treatment in young Swedish women.
Clin Oral Investig
January 2025
Department of Behavioral and Community Dentistry, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 450, Gothenburg, SE-40530, Sweden.
Objective: To investigate if changes in body mass index (BMI) result in changes of the mandibular trabecular bone structure.
Materials And Methods: Females (18-35 years at baseline, mean BMI 42,3) were followed from before (n = 117) until two years (n = 66) after obesity treatment (medical or surgical). The mandibular bone trabeculation was classified as sparse, dense, or mixed on intraoral radiographs (Lindh's index).
Genetic variations in IGF2BP2 and CAPN10 and their interaction with environmental factors increase gestational diabetes mellitus risk in Chinese women.
Gene
January 2025
Department of Immunology, Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, China. Electronic address:
Article Synopsis
- - This study explores the link between genetic variations in the IGF2BP2 and CAPN10 genes and the risk of gestational diabetes (GDM) among Chinese women, involving 1,566 participants.
- - Significant findings showed that the C allele of IGF2BP2/rs11927381 increased GDM risk, while the TC genotype of CAPN10/rs2975760 was linked to reduced risk, with both genes interacting in ways that heightened susceptibility to GDM.
- - Environmental factors, like increased BMI and specific exposures, were also found to elevate the risk of GDM, highlighting the complex interplay between genetics and environmental influences on this condition.
Associations of early life body size and pubertal timing with breast density and postmenopausal breast cancer risk: a mediation analysis.
Ann Epidemiol
January 2025
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Purpose: Whether breast density mediates associations between early life body size and pubertal timing with postmenopausal breast cancer is underexplored.
Methods: We studied 33,939 Danish women attending the Capital Mammography Screening Program at ages 50-69 years. Early life anthropometry and pubertal timing information came from the Copenhagen School Health Records Register.
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