The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, the role of ciRS-7 in esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival. Overexpression of ciRS-7 abrogated the tumor-suppressive roles of miR-7 including cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo. Mechanistically, ciRS-7 functioned as the sponge of miR-7 and reactivated its downstream HOXB13-mediated NF-κB/p65 pathway. Conclusively, our findings demonstrate how ciRS-7 induces malignant progression of ESCC and that ciRS-7 may act as a novel prognostic marker and therapeutic target for this lethal disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079012 | PMC |
| http://dx.doi.org/10.1038/s41419-018-0852-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Circular RNA CDR1as/ciRS-7- a novel biomarker in solid tumors.
Front Oncol
November 2024
Sichuan Provincial Key Laboratory for Human Disease Gene Study, Genome Sequencing Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Article Synopsis
- CDR1as/ciRS-7 is identified as an oncogenic regulator, and its expression correlates with poor clinical outcomes in various solid tumors based on a meta-analysis of 17 studies including 2424 patients.
- Higher levels of CDR1as/ciRS-7 are linked to increased tumor size, advanced TNM stage, and higher rates of lymph node and distant metastasis.
- The findings suggest that elevated CDR1as/ciRS-7 can serve as a poor prognostic marker in cancer, indicating a need for further investigation into its role in tumor progression.
Non-coding RNAs as therapeutic targets in Parkinson's Disease: A focus on dopamine.
Pathol Res Pract
November 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, AL Qassim 51452, Saudi Arabia. Electronic address:
Article Synopsis
- Parkinson's Disease (PD) is a complex neurological disorder characterized by the loss of dopamine-producing neurons, requiring new treatments beyond current symptom management.
- Non-coding RNAs (ncRNAs) are emerging as important regulators of gene expression and cellular processes, with specific types of ncRNAs showing potential roles in dopamine signaling and PD pathology.
- The review highlights the effects of deregulated miRNAs, the role of lncRNAs in dopaminergic neurons, and the novel circRNA ciRS-7, suggesting future therapeutic targets in ncRNAs to improve dopamine signaling and treatment for PD.
Several non-coding RNAs are known to be associated with the pathobiology and progression of multiple myeloma (MM). ciRS-7 (also known as CDR1-AS), a key oncogenic circular RNA (circRNA) that sponges miR-7-5p and other cancer-related microRNAs, was recently found to be downregulated in malignant plasma cells resistant to immunomodulatory drugs. Considering that various circRNAs have a strong potential as molecular biomarkers, we aimed to investigate the expression of ciRS-7 in plasma cell disorders, assess its prognostic importance in MM, and compare these findings with those of individuals with smoldering MM (SMM) and monoclonal gammopathy of unknown significance (MGUS).
View Article and Find Full Text PDFFunctional roles of conserved lncRNAs and circRNAs in eukaryotes.
Noncoding RNA Res
December 2024
Department of Clinical Laboratory, The First Affiliated Hospital of USTC, The RNA Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, Anhui, China.
Article Synopsis
- Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are essential regulators involved in various biological processes in eukaryotes.
- These non-coding RNAs function by influencing chromatin structure, regulating transcription, interacting with RNA-binding proteins, and acting as microRNA sponges.
- Studying conserved lncRNAs and circRNAs across different species can help deepen our understanding of their roles and mechanisms, which is often limited when focusing on just one species.
Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1α/VEGF signaling axis.
Heliyon
June 2024
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Background: Circular RNAs (circRNAs) hold potential as diagnostic markers for colorectal cancer (CRC); however, their functional mechanisms remain incompletely elucidated. This work investigates the clinical implications of a unique set comprising six circRNAs derived from serum in CRC. Furthermore, we delve into the role of exosomal circ_0084043, originating from colorectal cancer-associated fibroblasts (CAFs), with a specific focus on its contribution to endothelial cell angiogenesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!