Most family members code for antigens on melanoma tumor cells. is the black sheep, promiscuously found in normal adult cells, including neurons of the basal ganglia and prefrontal cortex. In this issue of , De Backer 1 propose an unexpected role for . Acute effects of cocaine, such as enhanced locomotion and reinforcement, are gone in mice in which the gene is deleted. In a painstaking combinatorial approach comparing several conditional gene knockout (KO) mouse lines, the authors parse the relevant neural circuits.
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