Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase.

Antimicrob Agents Chemother

EA7361 "Structure, Dynamic, Function and Expression of Broad Spectrum β-Lactamases, " Paris-Sud University, Faculty of Medicine, Le Kremlin-Bicêtre, France

Published: October 2018

OXA-535 is a chromosome-encoded carbapenemase of JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly related OXA-48-like carbapenemases. Comparison of and genetic environments suggests that an IS may be responsible for gene mobilization from the chromosome of spp. to plasmids.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153822PMC
http://dx.doi.org/10.1128/AAC.01198-18DOI Listing

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Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase.

Antimicrob Agents Chemother

October 2018

EA7361 "Structure, Dynamic, Function and Expression of Broad Spectrum β-Lactamases, " Paris-Sud University, Faculty of Medicine, Le Kremlin-Bicêtre, France

OXA-535 is a chromosome-encoded carbapenemase of JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535.

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