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Adoptive transfer of dendritic cells modulates immunogenesis and tolerogenesis in a neonatal model of murine cutaneous leishmaniasis.
Kinetoplastid Biol Dis
January 2005
Laboratorio de Biología Molecular, Instituto de Biomedicina, Universidad de Central Venezuela, Apartado 4043, Caracas 1010A, Venezuela.
We evaluated the adoptive transfer of DCs on -infected neonatal BALB/c mice. DCs were isolated and purified from the spleens of the following donor groups: a) Adult BALB/c mice infected during adulthood with ; b) Adult BALB/c mice infected during neonatal life; c) Healthy neonatal BALB/c mice; d) Healthy adult BALB/c mice. A neonatal model of infection, generated after inoculation with 5 × 10 promastigotes of , was used as the infection control group.
View Article and Find Full Text PDFEffect of trekrezan on immunogenesis under experimental conditions.
Bull Exp Biol Med
August 2004
Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences; Tartu University; Estonian Agricultural University, Tartu.
We studied the dynamics of immune reactions to trekrezan in mouse pups after vaccination of adult mice during pregnancy and mouse pups at different terms after birth with Salmonella typhimurium 34-96. The preparation modulated activity of the immune system and stimulated antibody production in the pre- and postnatal period.
View Article and Find Full Text PDF[Effect of cold on the antigen binding function of splenic cells at different periods of immunogenesis in rats].
Ross Fiziol Zh Im I M Sechenova
January 2003
Institute of Physiology, Russian Acad. Med. Sci., 4 Timakov St., Novosibirsk 630117, Russia.
The patterns of changes in the immune response when deep cooling with different rates acted at various periods during development of the immune response, were examined in Wistar rats. Cold exposure causes not only a suppression but also stimulation of the immune response to antigen. The suppressive effect of deep cooling when it preceded immune challenge (the antigen injected at a body temperature decreased by 3-4 degrees C) waned and became stimulating with increasing time interval between antigen challenge and cold exposure.
View Article and Find Full Text PDF[Alterations in diurnal sleep structure, electrical activity, and neurochemical parameters of the rat brain induced by systemic injection of complete Freund adjuvant and immunization by bovine serum albumin with complete Freund adjuvant].
Zh Vyssh Nerv Deiat Im I P Pavlova
February 2002
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Investigations of the effects of animal immunization with immunogenesis stimulator Freund's adjuvant complete (alone or in combination with bovine serum albumin often used in control experiments) on brain electrical activity, sleep, and neurochemical parameters were carried out in male Wistar rats. It was shown that both injection of Freund's adjuvant complete alone (0.25 ml) and immunization with bovine serum albumin (2 mg/kg in 0.
View Article and Find Full Text PDF[Changes in the neuromediator system of the thymus in rats after splenectomy].
Morfologiia
July 1998
Department of Medical Biology and Histology, Medical Institute, Chuvash State University, Cheboksrary.
Removal of spleen leads to compensatory activation of the function of central immunogenetic organ and increase of hyperplastic processes in it on d 3 postoperatively which is accompanied by growth of biogenic amine concentration, appearance of bioaminergic areas and lobules-satellites as well as formation of new cloe correlative links. Transitory inhibition of immunogenesis occurs on d 15 and d 30 peaking on d 45 following splenectomy. At this period glycosaminoglycan composition of mast cells and their functional activity changes which is manifested by appearance of juvenile T-0 forms and new metachromatic types of mast cells.
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