AI Article Synopsis
- The study investigated the phytochemicals in the methanol extract of Clausena lansium, identifying nine carbazole alkaloids, including two new ones called claulansiums A and B.
- The new compounds were characterized using advanced techniques like MS, NMR, IR, and UV, while known compounds were confirmed by comparing data with existing literature.
- The isolated compounds were tested for cytotoxic activity against A549 and Hela cancer cell lines, with compounds 2-6 showing significant cytotoxic effects at varying concentrations.
Article Abstract
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
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| http://dx.doi.org/10.1016/S1875-5364(18)30087-6 | DOI Listing |
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