Purpose: To determine the effect of altitude training at 1600 and 1800 m on sea-level (SL) performance in national-level runners.
Methods: After 3 wk of SL training, 24 runners completed a 3-wk sojourn at 1600 m (ALT1600, n = 8), 1800 m (ALT1800, n = 9), or SL (CON, n = 7), followed by up to 11 wk of SL racing. Race performance was measured at SL during the lead-in period and repeatedly postintervention. Training volume (in kilometers) and load (session rating of perceived exertion) were calculated for all sessions. Hemoglobin mass was measured via CO rebreathing. Between-groups differences were evaluated using effect sizes (Hedges g).
Results: Performance improved in both ALT1600 (mean [SD] 1.5% [0.9%]) and ALT1800 (1.6% [1.3%]) compared with CON (0.4% [1.7%]); g = 0.83 (90% confidence limits -0.10, 1.66) and 0.81 (-0.09, 1.62), respectively. Season-best performances occurred 5 to 71 d postaltitude in ALT1600/1800. There were large increases in training load from lead-in to intervention in ALT1600 (48% [32%]) and ALT1800 (60% [31%]) compared with CON (18% [20%]); g = 1.24 (0.24, 2.08) and 1.69 (0.65, 2.55), respectively. Hemoglobin mass increased in ALT1600 and ALT1800 (∼4%) but not CON.
Conclusions: Larger improvements in performance after altitude training may be due to the greater overall load of training in hypoxia compared with normoxia, combined with a hypoxia-mediated increase in hemoglobin mass. A wide time frame for peak performances suggests that the optimal window to race postaltitude is individual, and factors other than altitude exposure per se may be important.
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http://dx.doi.org/10.1123/ijspp.2018-0104 | DOI Listing |
Nutrients
December 2024
School of Health Sciences, University of Ioannina, St. Niarchou Av, 45500 Ioannina, Greece.
Unlabelled: Introduction-Aim: Adopting a lifestyle that incorporates regular physical activity confers substantial benefits to both physical and mental health and is recommended for prediabetic individuals. The aim of this study is to investigate the impact of activity tracking apps on increasing physical activity and its effect on glycemic control in people with prediabetes.
Materials And Methods: This pilot study included 37 participants, 18 in the prediabetic group and 19 in the normoglycemic group matched for age and gender (mean age 53 years, 40% males).
Nutrients
December 2024
Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital University Hospital, 29010 Málaga, Spain.
Background And Objectives: the COVID-19 pandemic underscored the necessity of understanding the factors influencing susceptibility and disease severity, as well as a better recovery of functional status, especially in postcritical patients. evidence regarding the efficacy of vitamin D supplementation in reducing the severity of COVID-19 is still insufficient due to the lack of primary robust trial-based data and heterogeneous study designs. the principal aims of our study were to determine the impact of vitamin D deficiency or insufficiency on complications during intensive care unit (icu) stay, as well as its role in muscle mass and strength improvement as well as morphofunctional recovery during a multispecialty 6-month follow-up program based on adapted nutritional support and specific physical rehabilitation.
View Article and Find Full Text PDFNutrients
December 2024
Division of General Medicine, Department of Internal Medicine, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Background/objectives: Oral frailty, first identified in Japan in 2014, refers to a state between healthy oral function and severe decline, marked by minor issues, such as tooth loss and chewing difficulties. The oral frailty five-item checklist (OF-5) enables non-dental professionals to evaluate oral frailty using five key indicators: remaining teeth count, chewing difficulties, swallowing difficulties, dry mouth, and articulatory oral skills. Limited studies exist.
View Article and Find Full Text PDFSupport Care Cancer
January 2025
Department of Medical Oncology, Heidelberg University Hospital and National Center for Tumor Diseases Heidelberg, a partnership between German Cancer Research Center (DKFZ) and University Medical Center Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Purpose: Physical performance is crucial for prognosis after allogeneic hematopoietic stem cell transplantation (allo-HCT). Cardiorespiratory fitness has already been shown to have prognostic value, and there is increasing evidence that muscle strength and associated parameters (e.g.
View Article and Find Full Text PDFDiabetes Ther
January 2025
Eli Lilly and Company, Indianapolis, IN, USA.
Introduction: The study objective was to describe characteristics and utilization patterns of tirzepatide users with type 2 diabetes (T2D) using the Healthcare Integrated Research Database in the USA.
Methods: Adults (≥18 years) included had T2D diagnosis; ≥1 tirzepatide claim (May 2022-January 2023; first claim date = index date); and continuous medical and pharmacy enrollment during the 6-month baseline and follow-up periods from the index date. Baseline demographics, clinical characteristics, and 6-month follow-up dosing and treatment patterns were summarized descriptively.
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