AI Article Synopsis
- Neuroendocrine tumors are rare cancers that can lead to complications like carcinoid syndrome and valve damage, but the timing for surgical repair is unclear.
- This study presents the first successful use of exercise cardiac MRI with pulmonary artery measurements to explore the effects of tricuspid valve insufficiency in a patient with minimal symptoms.
- Findings suggest that volume overload, rather than pressure, is critical in symptom development, leading to a recommendation for early tricuspid valve replacement to improve outcomes in carcinoid heart disease.
Article Abstract
Neuroendocrine tumours are a rare malignancy, which can be complicated by a carcinoid syndrome and, in more rare cases, also valve destruction. The correct timing for surgical repair remains unknown. We report the first-in-men exercise cardiac magnetic resonance imaging with pulmonary artery catheter measurements in order to better understand the haemodynamic impact of isolated tricuspid valve insufficiency in a low symptomatic patient. Not pressure but volume overload is the key factor in the development of symptoms, as long as the right ventricular function is intact. Based on our findings, we referred the patient for tricuspid valve replacement. This case, together with the review of all carcinoid heart disease cases in our hospital (a large tertiary cardiology and oncology centre) since 2000, indicates a potential benefit for early intervention in carcinoid heart disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165946 | PMC |
| http://dx.doi.org/10.1002/ehf2.12328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[An unusual tricuspid regurgitation].
G Ital Cardiol (Rome)
January 2025
U.O. Cardiologia, Dipartimento di Specialità Medico-Chirurgiche, Scienze Radiologiche e Sanità Pubblica, Università degli Studi, Brescia.
Tricuspid regurgitation can be due to different causes and mechanisms. Among these, cardiac involvement in carcinoid disease is a rare cause of tricuspid valve disease with a peculiar echocardiographic aspect. We report the case of a 59-year-old woman, with no past medical history, who was recently found to have a heart murmur and signs of right heart failure.
View Article and Find Full Text PDFPleural carcinoid diagnosed via video-assisted thoracoscopy biopsies in a patient with recurrent unilateral pleural effusion at St. Francis hospital Nsambya: a case report.
J Med Case Rep
December 2024
RineCynth Advisory Limited, Kampala, Uganda.
Background: Pulmonary carcinoids are rare neuroendocrine tumors accounting for less than 1% of all lung cancers. They are classified into two subcategories; typical and atypical carcinoids with the latter tending to grow faster. Historically, open thoracotomy was the standard approach for pulmonary resection.
View Article and Find Full Text PDFThe Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors.
Cancers (Basel)
November 2024
Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions), 00280 Helsinki, Finland.
Small intestinal neuroendocrine tumors (SI-NETs) are characterized by carcinoid syndrome and carcinoid heart disease (CHD). The aim of the present study was to identify early risk markers for carcinoid heart disease and survival in a prospective median-term follow-up setting. We measured 5-HIAA and cumulative 5-HIAA exposure (Cum-5-HIAA) based on repeated measurements, proBNP, vascular function, hepatic tumor load, and transthoracic echocardiography (TTE) at baseline and during the median 5-year follow-up.
View Article and Find Full Text PDFBackground: Following the publication of international cardio-oncology (CO) imaging guidelines, standard echocardiographic monitoring parameters of left ventricular systolic function have been endorsed. Recommendations highlight that either two-dimensional (2D) or three-dimensional (3D) left ventricular ejection fraction (LVEF), alongside global longitudinal strain (GLS) should be routinely performed for surveillance of patients at risk of cancer therapy-related cardiac dysfunction (CTRCD). We studied the feasibility of 3D-LVEF, 2D-GLS and 2D-LVEF in a dedicated CO service.
View Article and Find Full Text PDFCarcinoid Heart Disease Associated with Primary Ovarian Carcinoid Tumor: A Rare Presentation.
Heart Views
October 2024
Department of Cardiology, University Hospitals, Leicester, UK.
Article Synopsis
- - Primary ovarian carcinoid tumors are extremely rare, accounting for less than 0.1% of ovarian cancers, and often present with symptoms like abdominal pain and bloating.
- - A 54-year-old woman experienced dyspnea and edema, which were initially misdiagnosed as heart failure without classic carcinoid syndrome symptoms, but further tests indicated carcinoid disease.
- - Surgical treatment included valve repair and removal of reproductive organs, underscoring the importance of prompt diagnosis and intervention for managing complications like carcinoid heart disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!