Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs.
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http://dx.doi.org/10.7554/eLife.39664 | DOI Listing |
BMC Plant Biol
January 2025
Key Laboratory of National Forestry and Grassland Administration on Plant Ex Situ Conservation, Beijing Floriculture Engineering Technology Research Centre, Beijing Botanical Garden, Beijing, 100093, China.
Malania oleifera Chun et S.K. Lee is a woody oil tree species and is rich in nervonic acid, which is associated with brain development.
View Article and Find Full Text PDFAdv Physiol Educ
January 2025
Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA.
Generative large language models (LLMs) like ChatGPT can quickly produce informative essays on various topics. However, the information generated cannot be fully trusted as artificial intelligence (AI) can make factual mistakes. This poses challenges for using such tools in college classrooms.
View Article and Find Full Text PDFPrev Med Rep
November 2024
Center for Health Promotion and Health Equity, Department of Behavioral and Social Sciences, Brown University School of Public Health, United States.
Background: Consumption of ultra-processed foods (UPFs) is responsible for an increasing proportion of non-communicable diseases and premature mortality. Recognition of the commercial and social determinants of UPF consumption represents an important advance in public health, with implications for interventions that emphasize regulatory policies rather than individual motivation. However, it is important not to lose sight of the motivational mechanisms through which commercial and social determinants exert their effects on unhealthy behavior.
View Article and Find Full Text PDFMol Biotechnol
January 2025
Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
Nucleolin (NCL) is a prevalent and widely distributed nucleolar protein in cells. While primarily located in the nucleolus, NCL is also found within the nucleoplasm, cytoplasm, and even on the cell surface. NCL's unique nature arises from its multifaceted roles and extensive interactions with various proteins.
View Article and Find Full Text PDFVis Comput Ind Biomed Art
January 2025
Research Institute of Trustworthy Autonomous Systems and Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China.
Cataract is the leading ocular disease of blindness and visual impairment globally. Deep neural networks (DNNs) have achieved promising cataracts recognition performance based on anterior segment optical coherence tomography (AS-OCT) images; however, they have poor explanations, limiting their clinical applications. In contrast, visual features extracted from original AS-OCT images and their transform forms (e.
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