Introduction: Chronic open-angle glaucoma, also known as primary open-angle glaucoma (POAG) is an anterior optic neuropathy, chronic and progressive evolution, characterized by perimeter alterations and pathological optic cup, usually with an increase in intraocular pressure (IOP). Our study describes the epidemiological and clinical aspects of POAG in patients over 40 years old in the Institute of Tropical African Ophthalmology.
Materials And Methods: It was a prospective and descriptive study lasting two months including 200 patients with POAG, with the presence of at least one of the following three signs: intraocular pressure> 21mm Hg, disc cupping cup/disc vertical ≥0.5 and a visual field alteration apart from all other causes. All glaucoma patients seen during the study period benefited from a complete eye examination. The studied variables were family history of glaucoma, age, IOP and pachymetry.
Results: The study included 200 patients aged over 40 years old, with an average age of 57.6 years. Males were most represented (63.5%) with a sex ratio of 1.74. The primary reason for ophthalmologic consultation was a decrease in visual acuity (55.9%) followed by headaches (23.1%). More than a quarter of patients (29.5%) had a family history of glaucoma, approximately 2/3 of the patients had a lower pachymeter than normal (63% of cases), hypertension (66.5%) and diabetes (15%).
Conclusion: POAG, primarily characterised by previous medical conditions, namely hypertension and familial history of glaucoma, can lead to blindness if screening is delayed or if the treatment is badly delivered. Hence, the importance of prevention through screening and informing the population about the disease is necessary.
Download full-text PDF |
Source |
---|
Alzheimers Dement
December 2024
Federal Center of Brain and Neurotechnologies, FMBA of Russia, Moscow, Russian Federation.
Background: The priority problem of modern healthcare is irreversible dementia due to the steady increase in morbidity. Among irreversible dementias, Alzheimer's disease takes the first place. Most often, only with sufficiently pronounced cognitive disorders, the doctor can diagnose Alzheimer's disease, although it is obvious that the neurodegenerative process begins even before the clinical manifestations of the disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Background: Recent studies have identified visual impairment as a potentially modifiable dementia risk factor. However, the underlying mechanism linking visual impairment and cognitive decline is still not fully understood. Additionally, there has been a dearth of research focusing on Latinos.
View Article and Find Full Text PDFHum Mol Genet
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.
Primary open-angle glaucoma (POAG), known as a common ocular disease with genetic heterogeneity, is characterized by progressive optic disc atrophy and visual field defects. This study aimed to assess the contribution of previously reported POAG-associated genes and investigate potential functional variations and genotype-phenotype correlations in a Han Chinese population. DNA from 500 cases and 500 controls was pooled and sequenced using a customized panel of 398 candidate genes.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Ophthalmology, University Medical Centre Ljubljana, Grablovičeva 46, 1000 Ljubljana, Slovenia.
In open-angle glaucoma, the increase in intraocular pressure (IOP) is caused by an increased resistance to aqueous humour outflow in the trabecular meshwork. Since genetic variability of matrix metalloproteinase (MMP) genes may influence extracellular matrix remodelling, we investigated their association with glaucoma risk and/or response to treatment. The retrospective part of the study included patients with primary open-angle glaucoma and ocular hypertension (OHT); in the prospective part of the study, newly diagnosed patients with POAG or OHT were randomised to receive either latanoprost or selective laser trabeculoplasty (SLT) as the initial treatment.
View Article and Find Full Text PDFJ Clin Med
December 2024
Western Eye Hospital, 153-173 Marylebone Road, London NW1 5QH, UK.
: This paper will compare the outcomes-safety and efficacy-of three minimally invasive glaucoma surgeries (MIGSs),the Hydrus Microstent, iStent, and Gonioscopy-Assisted Transluminal Trabeculotomy (GATT), for intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG). : A literature search of Ovid Medline and Embase identified studies evaluating the Hydrus, iStent, and GATT. Data on IOP reduction, medication use, and complications were analyzed.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!