AI Article Synopsis
- SPTP, classified by the WHO in 1996, has gained attention due to its heterogeneous nature, with some cases showing aggressive behavior, though malignancy grading criteria are still unclear.
- Despite this, the overall prognosis for SPTP is favorable, allowing for long-term survival even post-recurrence and metastasis after surgery.
- The existing TNM staging system is not suitable for SPTP, creating challenges for research and individualized treatment approaches due to the absence of a predictive staging classification.
Article Abstract
Since solid pseudopapillary tumor of the pancreas (SPTP) was officially classified by the World Health Organization in 1996, SPTP has recently received special attention in the literature. Studies have shown that SPTP is a heterogeneous tumor, with a small percentage of patients harboring aggressive behaviors. However, criteria for malignancy grade in SPTP have not been well established. The prognosis of SPTP is generally good, with cases having a chance for long-term survival even with recurrence and/or metastasis after surgical resection. The current American Joint Committee on Cancer/Union for International Cancer Control tumor, node, metastasis staging system is not specific to SPTP. The lack of a predictive staging classification that accurately describes the heterogeneity of this disease hinders meaningful research into optimal individualized therapy. Here we summarize and discuss the associated factors proposed for appraisal of the malignant potential and adverse outcome of SPTP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068856 | PMC |
| http://dx.doi.org/10.4251/wjgo.v10.i7.184 | DOI Listing |
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