Synthesis of pentafluorosulfanyl (SF) containing aromatic amino acids.

J Fluor Chem

Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.

Published: August 2018

Herein, a series of aromatic pentafluorosulfanyl (SF) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of Pd(dba) and SPhos afforded the aforementioned SF amino acids in yields between 32% and 42%. Two dipeptides utilising both the amine and carboxylic functionalities of the synthesised SF containing amino acids were prepared, demonstrating their compatibility with common amide/peptide coupling reagents and strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039762PMC
http://dx.doi.org/10.1016/j.jfluchem.2018.06.006DOI Listing

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