AI Article Synopsis
- Pdgfra+ oligodendrocyte precursor cells (OPCs) develop in distinct waves during embryonic development in the central nervous system (CNS), but their relationship to different adult oligodendrocyte states is not well understood.
- Research utilizing bulk and single-cell transcriptomics reveals that post-natal OPCs from both the brain and spinal cord share similar transcriptional patterns, indicating a degree of similarity in their development.
- Additionally, some E13.5 Pdgfra+ cells were found to derive from the pericyte lineage, suggesting that these embryonic cells contribute to various post-natal cell types, including OPCs, across different regions of the CNS.
Article Abstract
Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104814 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2018.07.005 | DOI Listing |
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