AI Article Synopsis
- Periodontitis is a chronic inflammatory disease affecting the tissues around teeth, with interleukin-8 (IL-8) playing a crucial role in its development by influencing neutrophil activity in inflamed areas.
- The study assessed the relationship between specific genetic polymorphisms of IL-8 (−845 T/C and +781 C/T) and periodontitis in an Iranian population involving 65 patients and 55 controls.
- Results indicated that the +781 C/T variant may offer protection against periodontitis, while the presence of the C allele in the IL-8 −845 T/C polymorphism significantly increased the risk of developing the disease.
Article Abstract
Periodontitis is a chronic inflammatory disease that influences the protective tissues of teeth. IL-8, a member of the chemokine super-family, plays vital roles in the pathogenesis of periodontitis with activation and migration of neutrophils in inflammatory regions. The purpose of present study was to evaluate the association of interleukin-8 - 845 T/C and + 781 C/T polymorphisms with periodontitis in an Iranian population. A total of 65 patients with periodontitis including 18 patients with chronic periodontitis and 47 patients with aggressive periodontitis and 55 controls were enrolled into our study. Interleukin-8 - 845 T/C and + 781 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. For + 781C/T locus, in the dominant genetic model there was a significant difference between TT vs. CC + CT genotypes that significantly had a protective role against periodontitis disease with a value of 0.38 (95% CI 0.16-0.90, p = 0.02). Also, the analysis of results showed a significant positive association between the distribution of IL-8 - 845 T/C alleles and the risk of periodontitis disease (χ = 6.2, p = 0.01) that presence of C allele of IL-8 - 845 increased the risk of periodontitis disease by 9.08-fold [OR 9.08 (95% CI 1.14-72.12, p = 0.03)]. In conclusion, our results demonstrate a positive association between distribution of IL-8 - 845 T/C alleles and risk of periodontitis disease.
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| http://dx.doi.org/10.1007/s11033-018-4282-9 | DOI Listing |
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