Clinicians have attempted to find early preclinical physical diagnosis signs to detect vascular diseases at the preclinical stage and to prevent clinical deterioration in time. An interesting example of such signs is the Frank sign, which was first described by Dr Sonders T. Frank in 1973. Our goal was to summarize the clinical trials and observational studies that had examined the association between the Frank sign and cardiovascular diseases. Summarizing the 57 studies we found showed that this association could be used for early diagnosis of coronary and vascular diseases in the preclinical stage and that they were found in different populations around the world. Autopsy studies also found a strong association between the Frank sign and cardiovascular causes of death in both sexes. Cardiovascular causes of death included ischemic and hypertensive heart disease, calcific valvular stenosis, ruptured dissecting aneurysm of the thoracic aorta, and ruptured atheromatous aneurysm of the abdominal aorta. The Frank sign was correlated with increased intima-media thickness and stroke and was found in patients with peripheral vascular disease and with cardiovascular risk factors. The Frank sign could serve as a physical sign to help clinicians diagnose cardiovascular diseases.
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http://dx.doi.org/10.14423/SMJ.0000000000000845 | DOI Listing |
Int J Emerg Med
November 2024
Department of Emergency Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Introduction: In emergency medicine, triage encompasses more than the initial prioritization of treatment; it also includes decisions about the most suitable level of care and disposition for each patient. However, the increasing use of mobile technology by patients in the emergency department (ED) introduces a new factor. This study aims to explore the relationship between patients' cellphone use at the time of initial assessment and final disposition in the ED.
View Article and Find Full Text PDFDalton Trans
January 2025
Institut für Experimentelle Physik, TU Bergakademie Freiberg, Leipziger Straße 23, 09596 Freiberg, Germany.
YbRhSn crystallizes with a unique structural arrangement [space group 4/, = 9.6997(4) Å, = 13.7710(7) Å], which is related with primitive cubic YbRhSn and body-centered tetragonal (SnTb)TbRhSn types.
View Article and Find Full Text PDFJ Med Case Rep
November 2024
Department of Medical Oncology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Int J Geriatr Psychiatry
October 2024
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Objective: To investigate the association between suspected pseudobulbar affect (PBA), clinical diagnosis, cognitive testing, and self-reported mood in older adults presenting for evaluation of dementia.
Participants: Patients presenting to an outpatient memory disorders clinic (N = 311).
Methods: We used traditional and novel network modeling approaches to examine associations between neuropsychological (NP) tests, patient and clinician rating scales, and the Center for Neurological Study-Lability Scale (CNS-LS) among patients with suspected AD (n = 133) and other neurocognitive diagnosis (n = 178).
Sci Rep
October 2024
Department of Radiology and Neuroradiology, University Medical Center Schleswig Holstein, Campus Kiel, Arnold-Heller-Street 3, 24105, Kiel, Germany.
Emergency computed tomography (CT) often does not allow for comprehensive coronary artery assessment. However, CT may reveal pathological myocardial hypoperfusion suggestive of acute myocardial infarction (AMI), especially in patients presenting with a different diagnostic hypothesis. CT hypoperfusion is known to be associated with myocardial infarction, however the diagnostic value of CT hypoperfusion for the detection of AMI is still not well evaluated.
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