AI Article Synopsis

  • HIV was discovered in the 1980s and continues to impact many lives, but no effective drug is available for treatment.
  • Betulinic acid, found in various medicinal herbs and fruits, shows promising anti-HIV effects, attracting attention from pharmacists.
  • Some derivatives of betulinic acid have demonstrated strong inhibitory actions and are currently in phase II clinical trials, highlighting its potential for future research.

Article Abstract

Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches.

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http://dx.doi.org/10.1007/s11596-018-1891-4DOI Listing

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