PATRIOT is a phase I study of the ATR inhibitor, AZD6738, as monotherapy, and in combination with palliative radiotherapy. Here, we describe the protocol for this study, which opened in 2014 and is currently recruiting and comprises dose escalation of both drug and radiotherapy, and expansion cohorts.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068075 | PMC |
http://dx.doi.org/10.1016/j.ctro.2018.06.001 | DOI Listing |
J Clin Invest
January 2024
The Institute of Cancer Research, London, United Kingdom.
BACKGROUNDPhase 1 study of ATRinhibition alone or with radiation therapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia and Rad3-related) inhibitor ceralasertib (AZD6738) in advanced solid tumors.METHODSThe primary objective was safety. Secondary objectives included assessment of antitumor responses and pharmacokinetic (PK) and pharmacodynamic (PD) studies.
View Article and Find Full Text PDFBiol Sport
October 2023
Exercise Science and Athletic Training, Springfield College, Springfield, MA.
The purpose was to examine relationships between external loads (ELs), perceived exertion, and soreness. Collegiate men soccer players (n = 19) were monitored for 72 sessions (training: n = 53; matches: n = 19). Likert scale assessments (0-6) of lower body soreness were collected prior to each session, and ELs were collected using positional monitoring technology.
View Article and Find Full Text PDFJ Strength Cond Res
May 2021
Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, Virginia.
Merrigan, JJ, Tufano, JJ, and Jones, MT. Potentiating effects of accentuated eccentric loading are dependent upon relative strength. J Strength Cond Res 35(5): 1208-1216, 2021-The purpose was to evaluate the acute effects of accentuated eccentric loading (AEL) on bench press velocity and subsequent perceived effort (ratings of perceived exertion [RPE]) and soreness.
View Article and Find Full Text PDFFood Microbiol
February 2021
Department of Food Science, Rutgers University, 54 Dudley Road, New Brunswick, NJ, 08901-8520, USA.
A dynamic model to predict the germination and outgrowth of Clostridium botulinum spores in cooked ground beef was presented. Raw ground beef was inoculated with a ten-strain C. botulinum spore cocktail to achieve approximately 2 log spores/g.
View Article and Find Full Text PDFRadiother Oncol
August 2020
Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada; Institute of Health Policy Management and Evaluation, University of Toronto, Canada. Electronic address:
Background: Prostate stereotactic ablative radiotherapy (SABR) regimens differ in time, dose, and fractionation. We report an update of a multicentre, Canadian randomized phase II study to investigate the impact of overall treatment time on quality of life (QOL), efficacy, and toxicity.
Methods: Men with intermediate risk prostate cancer were randomized to 40 Gy in 5 fractions delivered every other day (EOD) versus once per week (QW).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!