Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus cf44-2.

One new bisabolane sesquiterpene, bisabolan-1,10,11-triol (), one new norbisabolane sesquiterpene, 12-nor-11-acetoxybisabolen-3,6,7-triol (), two new naturally occurring monoterpenes, (7)- and (7)-1-hydroxy-3--menthen-9-oic acids ( and ), one new naturally occurring trichodenone, dechlorotrichodenone C (), one new chlorine-containing trichodenone, 3-hydroxytrichodenone C (), one new diketopiperazine, methylcordysinin A (), and one new naturally occurring oxazole derivative, 4-oxazolepropanoic acid (), were isolated from the culture of a marine brown alga-endophytic strain (cf44-2) of . Their structures and relative configurations were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of ⁻ were assigned by analysis of the ECD spectra aided by quantum chemical computations. Compounds , , , and showed growth inhibition of some marine phytoplankton species and pathogenic bacteria.