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A new twist on superantigen-activated autoimmune disease.
J Clin Invest
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Division of Rheumatology, Center of Excellence for Intestinal and Immunology Research, University of Alberta, Edmonton, Alberta, Canada.
Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4+ T cells. Within the diseased joints, they found a marked enrichment of T cell receptor-variable β (TCR-Vβ) subsets that were reactive to the endogenously encoded mouse mammary tumor virus (MMTV) Sag.
View Article and Find Full Text PDFmechanism of action in alveolar bone destruction: Scoping review.
J Indian Soc Periodontol
December 2024
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta Pusat, Indonesia.
is implicated in periodontitis, a chronic inflammatory disease that destroys the periodontal tissue and alveolar bone due to host-microbe dysbiosis. This study focuses on understanding how contributes to bone destruction in periodontitis. The literature search was conducted using PubMed and Scopus databases based on Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines by entering preselected keyword combinations of inclusion and exclusion criteria.
View Article and Find Full Text PDFRole of high-dose amoxicillin dual therapy for eradication in an Irish cohort: A prospective study.
World J Clin Cases
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Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari 70124, Italy.
() infections may cause chronic gastritis, peptic ulcer disease, gastric cancers, and other conditions outside of the gastrointestinal tract. Hence, it is important to diagnose and treat it early. is resistant to certain drugs in traditional eradication therapy, so alternative therapy protocols are needed, such as high-dose amoxicillin dual therapy (HDADT).
View Article and Find Full Text PDFJanus-like behavior of intrinsically disordered regions in reticulophagy.
Autophagy
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School of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.
Intrinsically disordered regions (IDRs) are crucial to homeostatic and organellar remodeling pathways. In reticulophagy/ER-phagy, long cytosolic IDR-containing receptors (e.g.
View Article and Find Full Text PDFAspect based sentiment analysis datasets for Bangla text.
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Department of Computer Science and Engineering, Khulna University of Engineering & Technology, Khulna 9203, Bangladesh.
Sentiment analysis is becoming rapidly important for exploring social media Bangla text. The lack of sufficient resources is considered to be an important challenge for Aspect Based Sentiment Analysis (ABSA) of the Bangla language. The ABSA is a technique that divides the text and defines its sentiment based on its aspects.
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