The current study aims to investigate the aberrant driving behaviour and risk involvement of Iranian taxi drivers. The sample comprised 405 Iranian taxi drivers, who were recruited with a cross-sectional design, using a self-completion questionnaire survey during October and November 2016. We contribute to the literature by understanding how and to what extent the socioeconomic, demographic, driving, and aberrant driving behaviours influence risk involvement (accident involvement and traffic tickets). The validated 27-item Driver Behaviour Questionnaire (DBQ) was applied to measure aberrant driving behaviour. The results from valid observations ( = 381) explored a four-factor solution (including errors, ordinary violations, lapses, and aggressive violations) of the DBQ. The results also showed that being a single driver, having a high annual driving mileage, and a high number of daily taxi trips were positively associated with accident involvement. Furthermore, there was a positive correlation between the more ordinary violations and aggressive violations and accident involvement. Establishing better training and qualification mechanisms for taxi drivers could be considered by traffic safety experts in order to reduce ordinary and aggressive violations.
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http://dx.doi.org/10.3390/ijerph15081626 | DOI Listing |
Nat Cell Biol
January 2025
Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
Skin epithelial stem cells correct aberrancies induced by oncogenic mutations. Oncogenes invoke different strategies of epithelial tolerance; while wild-type cells outcompete β-catenin-gain-of-function (βcatGOF) cells, Hras cells outcompete wild-type cells. Here we ask how metabolic states change as wild-type stem cells interface with mutant cells and drive different cell-competition outcomes.
View Article and Find Full Text PDFComput Struct Biotechnol J
December 2024
Centre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia.
The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) at the National Institute of Chemistry (NIC) in Ljubljana represents a significant step forward, as it is the first centre of its kind in Slovenia. The CTGCT is poised to spearhead advances in cancer immunotherapy and personalised therapies for neurological and other rare genetic diseases.
View Article and Find Full Text PDFCell Mol Life Sci
January 2025
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
An aberrant pro-inflammatory microglia response has been associated with most neurodegenerative disorders. Identifying microglia druggable checkpoints to restore their physiological functions is an emerging challenge. Recent data have shown that microglia produce de novo neurosteroids, endogenous molecules exerting potent anti-inflammatory activity.
View Article and Find Full Text PDFSignal Transduct Target Ther
January 2025
Department of Life Science, University of Seoul, Seoul, South Korea.
Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates-membrane-less assemblies formed through the condensation of proteins, nucleic acids, and other molecules-in driving efficient and dynamic cellular processes. These condensates are integral to various physiological functions, such as gene expression and intracellular signal transduction, enabling rapid and finely tuned cellular responses.
View Article and Find Full Text PDFActa Neuropathol Commun
January 2025
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College (PUMC) and Chinese Academy of Medical Science (CAMS), Beijing, China.
Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but the underlying in vivo mechanisms remain unclear. This study examines the clinical features of ALS patients harboring the ANXA11 hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement.
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