Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121265 | PMC |
| http://dx.doi.org/10.3390/ijms19082249 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Green Light Activated Dual-Action Pt(IV) Prodrug With Enhanced PDT activity.
ChemMedChem
January 2025
Lomonosov Moscow State University: Moskovskij gosudarstvennyj universitet imeni M V Lomonosova, Chemistry, RUSSIAN FEDERATION.
Light induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt-based chemotherapeutic drugs. A combination of light-controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt-based chemotherapy and PDT via a synergetic effect. Herein we report green-light-activated Pt(IV) prodrug GreenPt with BODIPY-based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability.
View Article and Find Full Text PDFQuantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells laser ablation-ICP-mass spectrometry.
Dalton Trans
December 2024
Ghent University, Department of Chemistry, Atomic & Mass Spectrometry - A&MS Research Group, Belgium.
For years, cancer has been the second cause of death worldwide, preceded by cardiovascular diseases only. The number of research groups focusing on the discovery of new drugs to treat cancer is growing and the aim is to look for more effective compounds that cause less severe side effects and do not suffer from therapeutic resistance. The metal complexes cisplatin and carboplatin are widely used in the chemotherapeutic treatment of various types of cancer, including triple-negative breast cancer (TNBC).
View Article and Find Full Text PDFNovel platinum therapeutics induce rapid cancer cell death through triggering intracellular ROS storm.
Biomaterials
March 2025
Department of Nanomedicine, Houston Methodist Academic Institute, Houston, TX, 77030, USA. Electronic address:
Article Synopsis
- Induction of reactive oxygen species (ROS) is crucial for cancer treatment, but current methods are often ineffective due to low ROS production.
- Researchers have developed a new platinum-based drug called "carrier-platin," which uses nanoparticles to significantly boost ROS production in cancer cells, leading to rapid cell death (within 30 minutes).
- Unlike traditional platinum drugs that target DNA, carrier-platin kills cancer cells through a unique mechanism that bypasses DNA damage, showing enhanced effectiveness against a wide range of cancers, including those resistant to other treatments, with minimal side effects.
Azolato-Bridged Dinuclear Platinum(II) Complexes Exhibit Androgen Receptor-Mediated Anti-Prostate Cancer Activity.
Inorg Chem
November 2024
Laboratory of Biochemistry, Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Saitama 337-8570, Japan.
Prostate cancer is an androgen-dependent malignancy that presents a marked treatment challenge, particularly after progression to the castration-resistant stage. Traditional treatments such as androgen deprivation therapy often lead to resistance, necessitating novel therapeutic approaches. Previous studies have indicated that some of the azolato-bridged dinuclear platinum(II) complexes (general formula: [{-Pt(NH)}(μ-OH)(μ-azolato)]X, where azolato = pyrazolato, 1,2,3-triazolato, or tetrazolato and X = nitrate or perchlorate) inhibit androgen receptor (AR) signaling.
View Article and Find Full Text PDFSilanol-Stabilized Atomically Dispersed Pt-O-Sn Active Sites in Protozeolite for Propane Dehydrogenation.
J Am Chem Soc
September 2024
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
Crystalline zeolites have been proven to be excellent supports for confining subnanometric metal catalysts to boost the propane dehydrogenation (PDH) reaction. However, the introduced metallic species may suffer from severe sintering and limited stability during the catalytic process, especially when utilizing an industrial impregnation method for metal incorporation. In this study, we developed a new type of support based on amorphous protozeolite (PZ), taking advantage of its adjustable silanol chemistry and zeolitic microporous characteristic for stabilizing atomically dispersed PtSn catalyst via a simple, cost-effective coimpregnation process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!