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β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle. | LitMetric

AI Article Synopsis

  • The study investigates how β-hydroxybutyrate (β-HB), a ketone body, affects mitochondrial function in skeletal muscle cells, an area that has not been well-explored compared to neurological effects.
  • Findings show that β-HB boosts cell viability and improves mitochondrial health by reducing hydrogen peroxide (H₂O₂) emission and mitochondrial fission, possibly due to lower levels of ceramides.
  • Additionally, muscle tissue from rats on a sustained ketosis diet demonstrated lower H₂O₂ production while enhancing mitochondrial respiration, indicating overall improved mitochondrial function from β-HB as a fuel source.

Article Abstract

The clinical benefit of ketosis has historically and almost exclusively centered on neurological conditions, lending insight into how ketones alter mitochondrial function in neurons. However, there is a gap in our understanding of how ketones influence mitochondria within skeletal muscle cells. The purpose of this study was to elucidate the specific effects of β-hydroxybutyrate (β-HB) on muscle cell mitochondrial physiology. In addition to increased cell viability, murine myotubes displayed beneficial mitochondrial changes evident in reduced H₂O₂ emission and less mitochondrial fission, which may be a result of a β-HB-induced reduction in ceramides. Furthermore, muscle from rats in sustained ketosis similarly produced less H₂O₂ despite an increase in mitochondrial respiration and no apparent change in mitochondrial quantity. In sum, these results indicate a general improvement in muscle cell mitochondrial function when β-HB is provided as a fuel.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121962PMC
http://dx.doi.org/10.3390/ijms19082247DOI Listing

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