We study rare phase slips due to noise in synchronized Kuramoto oscillator networks. In the small-noise limit, we demonstrate that slips occur via large fluctuations to saddle phase-locked states. For tree topologies, slips appear between subgraphs that become disconnected at a saddle-node bifurcation, where phase-locked states lose stability generically. This pattern is demonstrated for sparse networks with several examples. Scaling laws are derived and compared for different tree topologies. On the other hand, for dense networks slips occur between oscillators on the edges of the frequency distribution. If the distribution is discrete, the probability-exponent for large fluctuations to occur scales linearly with the system size. However, if the distribution is continuous, the probability is a constant in the large network limit, as individual oscillators fluctuate to saddles while all others remain fixed. In the latter case, the network's coherence is approximately preserved.
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J Neurophysiol
February 2025
Biology Department and Volen Center, MS 013, Brandeis University, Waltham, Massachusetts, United States.
Animals must deal with numerous perturbations, oftentimes concurrently. In this study, we examine the effects of two perturbations, high extracellular potassium and elevated temperature, on the resilience of the pyloric rhythm of the crab, . At control temperatures (11°C), high potassium saline (2.
View Article and Find Full Text PDFProg Neurobiol
January 2025
Institute of Biomedical Investigations August Pi i Sunyer (IDIBAPS), Systems Neuroscience, 08036 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address:
Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from cortical slices of neocortical tissue from refractory epilepsy patients. Multi-electrode recordings were combined with histological information, providing a two-dimensional spatiotemporal characterization of human cortical dynamics in control conditions and following modulation of the excitation/inhibition balance.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFIET Syst Biol
January 2025
Center for Computational Biology, Department of Computational Biology, IIIT-Delhi, New Delhi, India.
One of the challenges that beset modelling complex biological networks is to relate networks to function to dynamics. A further challenge is deciphering the cellular function and dynamics that can change drastically when the network edge is tinkered with by adding or removing it. To illustrate this, the authors took a well-studied three-variable Goodwin oscillatory motif with only a negative feedback loop.
View Article and Find Full Text PDFNat Phys
December 2024
QuTech and Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
Direct interactions between quantum particles naturally fall off with distance. However, future quantum computing architectures are likely to require interaction mechanisms between qubits across a range of length scales. In this work, we demonstrate a coherent interaction between two semiconductor spin qubits 250 μm apart using a superconducting resonator.
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