Background: COPD physiopathology involves multiple pathways and evidence indicates that brain-derived neurotrophic factor (BDNF) is an important biomarker associated with parameters of COPD severity. This study aimed to analyze the time course of the effects of a pulmonary rehabilitation program (PRP) on BDNF levels and on functional status in COPD patients.
Methods: Patients were enrolled in a 24-session PRP. Exercise capacity, dyspnea, health-related quality of life, and the BODE index were assessed at baseline and after the PRP. BDNF plasma levels were measured at baseline (immediately before the 1 session), after the 1 session, and before and after the 24 session.
Results: Sixteen patients were included. A reduction in BDNF levels was observed after the 1 session and an increase was observed between the end of the 1 session and the beginning of the 24 session. The PRP promoted an improvement in exercise capacity and health-related quality of life and a reduction in dyspnea and the BODE index.
Conclusion: Exercise acutely reduced BDNF levels, an effect that was nullified by the overall intervention.
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