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Protocol of an adaptive mobile health intervention for the management of gestational weight gain: The LEAP cluster randomized controlled trial.
Contemp Clin Trials
December 2024
Kaiser Permanente Northern California, Division of Research, Pleasanton, CA, United States of America; UPSTREAM - Center for Upstream Prevention of Adiposity and Diabetes Mellitus; Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, United States of America.
Background: More than half of pregnant patients with overweight or obesity exceed national gestational weight gain (GWG) guidelines, increasing their risk of adverse outcomes. There is an urgent need to develop effective and scalable interventions to improve GWG.
Objective: To describe the protocol of Lifestyle, Eating, and Activity in Pregnancy (LEAP), a cluster randomized controlled trial evaluating a mobile health (mHealth) intervention promoting appropriate GWG in an integrated healthcare system.
Prediction of the octanol-water partition constant of neutral compounds by reversed-phase liquid chromatography using alternative organic solvent modifiers.
J Chromatogr A
December 2024
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Reversed-phase liquid chromatography (RPLC) offers significant advantages over traditional methods for estimating octanol-water partition constants, which are a critical parameter in drug discovery. In contrast to classical methods for determining the octanol-water partition constant, such as shake-flask techniques, RPLC is less time-consuming and easier to automate. In this study, we explored three alternative organic solvent modifiers: acetone, 2-propanol, and tetrahydrofuran for the indirect determination of the octanol-water partition constant for neutral compounds by RPLC using either isocratic retention factors or retention factors extrapolated to 100 % water for several stationary phases.
View Article and Find Full Text PDFComparative genome analyses of Staphylococcus aureus from platelet concentrates reveal rearrangements involving loss of type VII secretion genes.
Access Microbiol
September 2024
Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.
has been involved in transfusion-transmitted fatalities associated with platelet concentrates (PCs) due to its heightened pathogenicity enhanced by genome-encoded virulence and antibiotic resistance genes. This may be facilitated by mobile genetic elements (MGEs) that can cause rearrangements. Several factors contribute to virulence, including the type VII secretion system (T7SS), composed of six core genes conserved across strains.
View Article and Find Full Text PDFGenomic Insights into a Multidrug-Resistant Escherichia coli of sequence type 155: A Ceftazidime-Avibactam Resistant Strain Harboring Four Classes of β-Lactamases.
J Glob Antimicrob Resist
December 2024
Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing, China. Electronic address:
Objective: The emergence of multidrug-resistant (MDR) Escherichia coli strains has significantly constrained antibiotic treatment options, while the spread of antimicrobial resistance genes (ARGs) and mobile genetic elements exacerbates the situation. This study delves into an MDR E. coli strain, QMM-01, which uniquely co-expresses β-lactamases from all four recognized classes, aiming to uncover the underlying mechanisms of its resistance and assess its potential for global spread.
View Article and Find Full Text PDFCounterfactual rewards promote collective transport using individually controlled swarm microrobots.
Sci Robot
December 2024
Department of Physics, University of Konstanz, Universitaetsstrasse 10, Konstanz, 78464, Germany.
Swarm robots offer fascinating opportunities to perform complex tasks beyond the capabilities of individual machines. Just as a swarm of ants collectively moves large objects, similar functions can emerge within a group of robots through individual strategies based on local sensing. However, realizing collective functions with individually controlled microrobots is particularly challenging because of their micrometer size, large number of degrees of freedom, strong thermal noise relative to the propulsion speed, and complex physical coupling between neighboring microrobots.
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