A design process for creating integrated diffractive focusing elements for use in planar waveguides is presented. The elements consist of a linear array of holes etched into the core layer of a planar dielectric waveguide. A complete element is a few micrometers in size, while the individual holes are sub-micrometer. The focusing element was designed using analytical Mie theory. The performance of the complete 3D structure was then evaluated using 3D finite difference time domain (FDTD) method. A focal spot width of 227 nm (full width at half maximum) was predicted by 3D FDTD simulations with a peak intensity more than 10x the incident intensity and back-reflections lower than 1%. The focusing elements were fabricated using electron beam lithography and plasma etching. Fluorescence imaging was used to map the intensity in the waveguide core. The experimentally measured intensity maps were in good agreement with the simulations when the finite spatial resolution of the imaging system was taken into account.
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http://dx.doi.org/10.1364/OL.43.003477 | DOI Listing |
Geroscience
January 2025
Dept. of Bioinformatics, Semmelweis University, 1094, Budapest, Hungary.
Age-related cognitive impairment and dementia pose a significant global health, social, and economic challenge. While Alzheimer's disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals the considerable impact of vascular cognitive impairment and dementia (VCID), which now accounts for nearly half of all dementia cases. The Mediterranean diet-characterized by high consumption of fruits, vegetables, whole grains, fish, and olive oil-has been widely recognized for its cardiovascular benefits and may also reduce the risk of cognitive decline and dementia.
View Article and Find Full Text PDFExpert Opin Drug Deliv
January 2025
Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK.
Introduction: mRNA therapeutics were a niche area in drug development before COVIDvaccines. Now they are used in vaccine development, for non-viral therapeuticgenome editing, chimericantigen receptor T (CAR T) celltherapies and protein replacement. mRNAis large, charged, and easily degraded by nucleases.
View Article and Find Full Text PDFJ Clin Med
December 2024
Division of Cardiovascular Medicine, Tufts Medical Center, Boston, MA 02111, USA.
: Heart failure is the leading cause of hospital admission and mortality. Racial disparities have been demonstrated in various cardiovascular disorders; however, the data for in-hospital outcomes, complications, and procedural rates are limited. : Utilizing the National Inpatient Sample (NIS) database, this retrospective cohort study included adult patients admitted with a principal diagnosis of heart failure.
View Article and Find Full Text PDFSensors (Basel)
January 2025
University of Zagreb, Faculty of Transport and Traffic Sciences, Vukelićeva 4, 10000 Zagreb, Croatia.
The possibilities of the Ambient Assisted Living (AAL)/Enhanced Living Environments (ELE) concept in the environment of a smart home were investigated to improve accessibility and improve the quality of life of a person with disabilities. This paper focuses on the concept of predictive information for a person with disabilities in a smart home environment concept where artificial intelligence (AI) and machine learning (ML) systems use data on the user's preferences, habits, and possible incident situations. A conceptual mathematical model is proposed, the purpose of which is to provide predictive user information from defined data sets.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Acropolis Restoration Service, Hellenic Ministry of Culture, 10555 Athens, Greece.
This study focuses on the geotechnical evaluation of the foundation conditions of the Agrippa Monument at the Acropolis of Athens, aiming to propose interventions to improve stability and reduce associated risks. The assessment reveals highly uneven foundation conditions beneath the monument. A thorough collection of bibliographic references and geotechnical surveys was conducted, classifying geomaterials into engineering-geological units and evaluating critical parameters for geotechnical design.
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