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| http://dx.doi.org/10.1002/JLB.5CE0418-162R | DOI Listing |
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Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Bone is a frequent site for metastatic development in various cancer types, including breast cancer, with a grim prognosis due to the distinct bone environment. Despite considerable advances, our understanding of the underlying processes leading to bone metastasis progression remains elusive. Here, we applied a bioactive three-dimensional (3D) model capable of mimicking the endosteal bone microenvironment.
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Department of Research and Development, THAI StemLife Co., Ltd., Bangkok 10310, Bangkok, Thailand.
Type 2 diabetes mellitus (T2DM) is a lifelong condition and a grave threat to human health. Innovative efforts to relieve its detrimental effects are acutely needed. The in T2DM management is consistent adherence to a prudent lifestyle and nutrition, combined with aerobic and resistance exercise regimens, together repeatedly shown to lead to complete reversal and even long-term remission.
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SARChI Chair for Inclusive Cities, School of Built Environment & Development Studies, College of Humanities, University of KwaZulu-Natal, Durban, South Africa.
The poverty-as-a-vaccine hypothesis came to light following the wide circulation of the controversial British Broadcasting Corporation (BBC) World Service post on the internet and social media. It was a theoretical response to what this paper has termed as "the African COVID-19 paradox" or what some have characterised as the "African COVID-19 anomaly" whose thesis is though Africa is the poorest continent in the world, yet it has some of the lowest COVID-19 infection and mortality rates globally. This paradoxical profile apparently contradicts earlier and grim projections by several international bodies on the fate of Africa in this global health crisis.
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Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal and grim overall prognosis and survival rate, which have remained virtually unchanged for over half a century. PDAC is the most lethal of all cancers, with the highest mortality-to-incidence ratio. PDAC responds poorly to current therapies and remains an incurable malignancy.
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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139;
Dendritic cell (DC) lectins mediate the recognition, uptake, and processing of antigens, but they can also be coopted by pathogens for infection. These distinct activities depend upon the routing of antigens within the cell. Antigens directed to endosomal compartments are degraded, and the peptides are presented on major histocompatibility complex class II molecules, thereby promoting immunity.
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