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What are the advantages of living in a community? A microbial biofilm perspective! | LitMetric

AI Article Synopsis

  • Biofilms are resilient structures formed by microorganisms, including harmful pathogens, that provide various advantages like enhanced adhesion, nutrient sharing, and protection against drugs and immune responses.
  • They pose significant challenges in healthcare settings, leading to increased costs and prolonged hospital stays due to secondary infections.
  • The text emphasizes the necessity for both public and private investments in developing new treatment strategies to tackle the issues caused by biofilm-associated infections in patients.

Article Abstract

Biofilm formation is the preferred mode of growth lifestyle for many microorganisms, including bacterial and fungal human pathogens. Biofilm is a strong and dynamic structure that confers a broad range of advantages to its members, such as adhesion/cohesion capabilities, mechanical properties, nutritional sources, metabolite exchange platform, cellular communication, protection and resistance to drugs (e.g., antimicrobials, antiseptics, and disinfectants), environmental stresses (e.g., dehydration and ultraviolet light), host immune attacks (e.g., antibodies, complement system, antimicrobial peptides, and phagocytes), and shear forces. Microbial biofilms cause problems in the hospital environment, generating high healthcare costs and prolonged patient stay, which can result in further secondary microbial infections and various health complications. Consequently, both public and private investments must be made to ensure better patient management, as well as to find novel therapeutic strategies to circumvent the resistance and resilience profiles arising from biofilm-associated microbial infections. In this work, we present a general overview of microbial biofilm formation and its relevance within the biomedical context.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057313PMC
http://dx.doi.org/10.1590/0074-02760180212DOI Listing

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