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Protein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target.
Theranostics
January 2025
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The tumor microenvironment (TME) is involved in cancer initiation and progression. With advances in the TME field, numerous therapeutic approaches, such as antiangiogenic treatment and immune checkpoint inhibitors, have been inspired and developed. Nevertheless, the sophisticated regulatory effects on the biological balance of the TME remain unclear.
View Article and Find Full Text PDFReplication Crisis in Psychology, Second-Order Cybernetics, and Transactional Causality: from Experimental Psychology to Applied Psychological Practice.
Integr Psychol Behav Sci
January 2025
Department of Psychology, Panteion University, Athens, Greece.
This article aims to reconceptualize the replication crisis as not merely a problem of flawed methods, lack of scientific rigor, or questionable researcher conduct, but as a fundamentally epistemological and philosophical issue. While improved methodologies and scientific practices are necessary, they must be considered through the lens of the underlying epistemologies. Toward this end, a new paradigm for psychological research and practice, grounded in second-order cybernetics and transactional causality, is proposed as instrumental.
View Article and Find Full Text PDFMedication Hazards and Outcome Patterns of Pediatric Drug-Associated Liver Injury in Taiwan: An Analysis of 1998-2017 Spontaneous Adverse Drug Reaction Reports.
Drugs Real World Outcomes
January 2025
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 100025, Taiwan.
Background And Objectives: Accumulating pediatric efficacy and safety data on drug use is inherently challenging yet essential. This study aimed to analyze the frequency and compute the odds of pediatric drug-associated liver injury across age groups (early childhood, middle childhood, and adolescence) and therapeutic categories using adverse drug reactions (ADRs) reporting data spanning nearly two decades.
Methods: We analyzed the reports of suspected ADRs occurring in children and adolescents in the Taiwan National Adverse Drug Reaction Reporting System during the period from May 1998 until July 2017.
Development and Psychometric Properties of the Pain and Sensitivity Reactivity Scale in a Diverse Sample of Autistic People.
Children (Basel)
December 2024
Hospital Pediatric Service University General "Los Arcos", 30739 San Javier, Spain.
Background: Recent studies indicate the need to examine how the gut microbiota-brain axis is implicated in pain, sensory reactivity and gastro-intestinal symptoms in autism spectrum disorder (ASD), but no scale exists that assesses all these constructs simultaneously.
Methods: We created a pool of 100 items based on the real-world experience of autistic people, and a multidisciplinary team and stakeholders reduced this pool to 50 items assessing pain, sensory hypersensitivity, and sensory hyposensitivity. In the present study, we present this new assessment tool, the Pain and Sensitivity Reactivity Scale (PSRS), and examine its psychometric properties in a sample of 270 individuals with autism spectrum disorder (ASD; mean age = 9.
Solving the Independent Domination Problem by the Quantum Approximate Optimization Algorithm.
Entropy (Basel)
December 2024
School of Mathematical Sciences, Key Laboratory of MEA (Ministry of Education) & Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai 200241, China.
In the wake of quantum computing advancements and quantum algorithmic progress, quantum algorithms are increasingly being employed to address a myriad of combinatorial optimization problems. Among these, the Independent Domination Problem (IDP), a derivative of the Domination Problem, has practical implications in various real-world scenarios. Despite this, existing classical algorithms for the IDP are plagued by high computational complexity, and quantum algorithms have yet to tackle this challenge.
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