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Immunopathogenesis of Human Sporotrichosis: What We Already Know. | LitMetric

Immunopathogenesis of Human Sporotrichosis: What We Already Know.

J Fungi (Basel)

Laboratory of Leishmaniasis Research, Oswaldo Cruz Institute, IOC/Fiocruz, Avenida Brasil 4365 Pavilhão 26 sala 509-Manguinhos, Rio de Janeiro 21040-360, Brazil.

Published: July 2018

AI Article Synopsis

  • - Sporotrichosis is a chronic fungal infection caused by a dimorphic fungus that affects both humans and domestic animals, with increasing cases observed globally, particularly from cat scratches or bites.
  • - In humans, the disease primarily manifests in the skin, presenting mainly as lymphocutaneous and fixed forms, but can also affect other tissues, leading to rarer forms.
  • - The review emphasizes the importance of understanding the immune response of the host and the fungus's evasion strategies to improve control and management of sporotrichosis.

Article Abstract

Sporotrichosis is a subacute/chronic mycosis caused by dimorphic fungus of the genus This mycosis may affect both human and domestic animals and in the last few years, the geographic dispersion and increase of sporotrichosis worldwide has been observed. The occurrence of cases related to scratching/bites of domestic felines have increased, characterizing the disease as predominantly a zoonosis. In humans, sporotrichosis mainly involves the cutaneous tegument of infected patients, but other tissues may also present the infection. The main forms of clinical presentation are lymphocutanous sporotrichosis (LC) and fixed sporotrichosis (F). Although less common, mucosal, cutaneous disseminated, and extracutaneous forms have also been described. Multiple factors from the fungus and host can play a role in driving the clinical evolution of sporotrichosis to benign or severe disease. In this review, we discuss the immunopathological aspects involved in human sporotrichosis. Putting together the two branches of knowledge-host immune response and fungal evading mechanisms-we may perceive new possibilities in understanding the fungus⁻host interaction in order to be in a position to go further in the control of sporotrichosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162489PMC
http://dx.doi.org/10.3390/jof4030089DOI Listing

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