Activation of EGFR (epidermal growth factor receptor) and Eph receptor often exerts opposing effects on cell functions. In this issue of , Stallaert reveal how cells maintain sustained response to EGF stimulation by replenishing EGFR at the plasma membrane and how conflicting signals from the EphA-ephrin system and EGFR are integrated to coordinate cellular responses, including cell migration and proliferation.
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Environmental enrichment improves social isolation-induced memory impairment: The possible role of ITSN1-Reelin-AMPA receptor signaling pathway.
PLoS One
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Behavioural Neuroscience Laboratory, Department of Animal Science, Bharathidasan University, Tiruchirappalli, India.
Environmental enrichment (EE) through combination of social and non-biological stimuli enhances activity-dependent synaptic plasticity and improves behavioural performance. Our earlier studies have suggested that EE resilience the stress induced depression/ anxiety-like behaviour in Indian field mice Mus booduga. This study was designed to test whether EE reverses the social isolation (SI) induced effect and improve memory.
View Article and Find Full Text PDFBerberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1α/VEGF activation in retina endothelial cells.
Int J Biol Sci
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School of Chinese Medicine, The University of Hong Kong.
Insulin therapy is the major treatment of glycaemic control in type I diabetes mellitus (DM) and advanced type II DM patients who fail to respond to oral hypoglycemic agents. Nonetheless, insulin therapy is deemed unsuccessful in controlling the incidence of diabetic retinopathy (DR) and is likely a risk factor. Berberine, an isoquinoline alkaloid, has caught great attention towards its anti-diabetic mechanisms.
View Article and Find Full Text PDFIdentification of the Role of Wnt/β-Catenin Pathway Through Integrated Analyses and in vivo Experiments in Vitiligo.
Clin Cosmet Investig Dermatol
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Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Article Synopsis
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Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats.
J Cell Mol Med
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Department of Endocrinology, Shanghai 10th People Hospital, Tongji University School of Medicine, Shanghai, China.
It was reported that either orexigenic neuropeptide galanin or anorexigenic hormone leptin caught benefit insulin sensitivity through increasing the translocation of glucose transporter 4 (GLUT4) in patients with diabetes. To date, it is unknown whether galanin can potentiate the effect of leptin on alleviation of insulin resistance. Therefore, in the current study we sought to assess the combined effect of central leptin and galanin on insulin resistance in the adipose tissues of type 2 diabetic rats.
View Article and Find Full Text PDFOffspring from maternal nutrient restriction in mice show variations in adult glucose metabolism similar to human fetal growth restriction.
J Dev Orig Health Dis
August 2019
Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University,London, ON,Canada.
Fetal growth restriction (FGR) is a pregnancy condition in which fetal growth is suboptimal for gestation, and this population is at increased risk for type 2 diabetes as adults. In humans, maternal malnutrition and placental insufficiency are the most common causes of FGR, and both result in fetal undernutrition. We hypothesized that maternal nutrient restriction (MNR) in mice will cause FGR and alter glucose metabolism in adult offspring.
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